By plane
Jaime González Airport has three flights a week: leaving Miami at 8am Mondays and Fridays, returning 10:45am; and leaving Miami 5:30pm Wednesdays and returning later in the evening 8pm?. A roundtrip ticket is $509. The airline is a charter. The telephone number is 800 493 8426, the website is (http://www.destinationcub...).
By train
There are two trains that run from Havana: a very slow daytime train every second day that returns the following day, and a somewhat faster late-evening train every second day that operates via Matanzas and returns overnight. Trains may also leave for Santa Clara very early in the morning and return in the evening, and leave for Santa Clara and Sancti Spiritus in the afternoon, returning the following morning. Check that the trains are running in advance.
By bus
The two daily Viazul (http://www.viazul.com/) buses between Havana and Trinidad stop at Cienfuegos, as does the daily bus between Varadero, Santa Clara, and Trinidad. This last bus arrives from Varadero heading for Trinidad at noon, and arrives from Trinidad heading for Varadero at 4:00pm it is missing from the Viazul website. Travellers heading east and wishing to catch the 8:00am Viazul bus from Trinidad to Santiago de Cuba can sometimes arrange for an early morning minivan through Viazul. Ask at the bus station.